{"id":7742,"date":"2021-11-02T16:08:39","date_gmt":"2021-11-02T08:08:39","guid":{"rendered":"https:\/\/www.hermes.com.tw\/?p=7742"},"modified":"2021-11-11T10:51:52","modified_gmt":"2021-11-11T02:51:52","slug":"2021-nobel-prize","status":"publish","type":"post","link":"https:\/\/www.hermes.com.tw\/zh-hans\/2021-nobel-prize\/","title":{"rendered":"\u8bfa\u8d1d\u5c14\u751f\u533b\u5956 \u6e29\u5ea6\u5230\u89e6\u89c9\u7684\u53d1\u73b0"},"content":{"rendered":"<p>(\u672c\u6587\u8f6c\u8f7d\u81ea\u6cdb\u79d1\u5b66 PanSci)<\/p>\n<p>2021\u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u6216\u533b\u5b66\u5956\uff08Physiology or Medicine\uff09\uff0c\u7531\u7f8e\u56fd\u751f\u7406\u5b66\u5bb6\u6731\u91cc\u96c5\u65af\uff08David Julius\uff09\u53ca\u5e15\u5854\u666e\u8482\u5b89\uff08Ardem Patapoutian\uff09\u5171\u540c\u83b7\u5956\uff0c\u4ed6\u4eec\u7684\u7814\u7a76\u9996\u5ea6\u53d1\u73b0\u4e86\u300c\u4eba\u7c7b\u795e\u7ecf\u7cfb\u7edf\u7684\u6e29\u5ea6\u548c\u89e6\u89c9\u53d7\u4f53\u300d\u3002<\/p>\n<p>\u4eba\u7c7b\u611f\u53d7\u51b7\u70ed\u53ca\u89e6\u89c9\u7684\u80fd\u529b\u662f\u4e0e\u751f\u4ff1\u6765\u3001\u4e14\u5bf9\u751f\u5b58\u800c\u8a00\u662f\u81f3\u5173\u91cd\u8981\u7684\u80fd\u529b\u3002\u4f46\u5173\u4e8e\u300c\u6e29\u5ea6\u548c\u673a\u68b0\u6027\u523a\u6fc0\u5982\u4f55\u5728\u795e\u7ecf\u7cfb\u7edf\u4e2d\u8f6c\u5316\u4e3a\u7535\u8109\u51b2\u4fe1\u53f7\uff1f\u300d\uff08\u5916\u5728\u523a\u6fc0\u5982\u4f55\u8f6c\u4e3a\u751f\u7406\u611f\u53d7\u7684\u673a\u5236\uff09\u4e00\u76f4\u662f\u60ac\u800c\u672a\u89e3\u7684\u96be\u9898\u3002<\/p>\n<p>\u6731\u91cc\u96c5\u65af\u5229\u7528\u8fa3\u6912\u7d20\uff08capsaicin\uff09\u6765\u8bc6\u522b\u76ae\u80a4\u795e\u7ecf\u672b\u68a2\u4e2d\u5bf9\u300c\u70ed\u300d\u6709\u53cd\u5e94\u7684\u53d7\u4f53\uff1b\u5e15\u5854\u666e\u8482\u5b89\u5219\u4f7f\u7528\u538b\u654f\u7ec6\u80de\uff08pressure-sensitive cells\uff09\u53d1\u73b0\u4e86\u65b0\u578b\u53d7\u4f53\uff0c\u53ef\u4ee5\u5bf9\u76ae\u80a4\u548c\u5185\u90e8\u5668\u5b98\u4e2d\u7684\u673a\u68b0\u529b\u523a\u6fc0\uff08mechanical stimuli\uff09\u505a\u51fa\u53cd\u5e94\uff0c\u8ba9\u6211\u4eec\u77e5\u9053\u529b\u5b66\u7684\u523a\u6fc0\u4e5f\u4f1a\u8fde\u7ed3\u5230\u5bf9\u5e94\u7684\u53d7\u4f53\u3002<\/p>\n<p><strong>\u300c\u8fa3\u6912\u7d20\u300d\u5982\u4f55\u4ea7\u751f\u707c\u70ed\u611f\uff1f<br \/>\n<\/strong><br \/>\n\u5728 1990 \u5e74\u4ee3\u540e\u671f\uff0c\u52a0\u5229\u798f\u5c3c\u4e9a\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u7684\u6731\u91cc\u96c5\u65af\uff0c\u901a\u8fc7\u5206\u6790\u8fa3\u6912\u7d20\u5982\u4f55\u5f15\u53d1\u63a5\u89e6\u8fa3\u6912\u65f6\u7684\u707c\u70e7\u611f\uff0c\u8fd9\u9879\u7814\u7a76\u5f00\u542f\u4e86\u540e\u7eed\u300c\u6e29\u5ea6\u5dee\u5bf9\u7279\u5b9a\u611f\u89c9\u53d7\u4f53\u4e4b\u95f4\u7684\u5173\u8054\u6027\u300d\u7684\u7814\u7a76\u3002<\/p>\n<p>\u4f17\u6240\u7686\u77e5\uff0c\u8fa3\u6912\u7d20\u80fd\u6fc0\u53d1\u795e\u7ecf\u7ec6\u80de\u5e76\u5f15\u8d77\u75bc\u75db\u611f\u4e0e\u707c\u70ed\u611f\uff0c\u4f46\u8be6\u7ec6\u7684\u539f\u7406\u673a\u5236\u5728\u5f53\u65f6\u662f\u4e00\u4e2a\u672a\u89e3\u4e4b\u8c1c\u3002\u6731\u91cc\u96c5\u65af\u548c\u4ed6\u7684\u540c\u4e8b\uff0c\u5efa\u6784\u4e86\u5305\u542b\u6570\u767e\u4e07\u4e2a DNA \u7247\u6bb5\u7684\u6570\u636e\u5e93\uff0c\u5e76\u627e\u5230\u7247\u6bb5\u4e2d\u5bf9\u5e94\u4e8e\u7279\u5b9a\u795e\u7ecf\u5143\u6765\u8868\u8fbe\u611f\u89c9\u7684\u53d7\u4f53\uff0c\u8fd9\u4e9b\u53d7\u4f53\u53ef\u4ee5\u5bf9\u75bc\u75db\u3001\u70ed\u548c\u89e6\u78b0\u505a\u51fa\u53cd\u5e94\u3002\u4ed6\u4eec\u900f\u8fc7\u6bd4\u5bf9\u7ec6\u80de\u5bf9\u8fa3\u6912\u7d20\u7684\u53cd\u5e94\uff0c\u5206\u6790\u5176 DNA \u5dee\u5f02\uff0c\u7ecf\u7814\u7a76\u540e\uff0c\u6731\u91cc\u4e9a\u65af\u7814\u7a76\u56e2\u961f\u786e\u5b9a\u4e86\u4e00\u7ec4\u4f1a\u8ba9\u7ec6\u80de\u5bf9\u8fa3\u6912\u7d20\u654f\u611f\u7684\u53d7\u4f53\u3002<\/p>\n<p>\u8fd9\u4e2a\u65b0\u53d1\u73b0\u7684\u8fa3\u6912\u7d20\u53d7\u4f53\uff0c\u540e\u6765\u88ab\u547d\u540d\u4e3a TRPV1\u3002\u5f53\u6731\u91cc\u96c5\u65af\u7814\u7a76 TRPV1 \u5bf9\u70ed\u7684\u53cd\u5e94\u65f6\uff0c\u53d1\u73b0 TRPV1 \u4f1a\u5728\u5927\u4e8e\u6444\u6c0f 43 \u5ea6\u65f6\u88ab\u6fc0\u53d1\uff0c\u4ed6\u610f\u8bc6\u5230\u4ed6\u53d1\u73b0\u4e86\u4e00\u79cd\u70ed\u654f\u53d7\u4f53\uff0c\u8fd9\u79cd\u53d7\u4f53\u5728\u7279\u5b9a\u7684\u6e29\u5ea6\u4e0b\u4f1a\u6fc0\u53d1\u75bc\u75db\u611f\uff08\u56fe 1\uff09\u3002<\/p>\n<figure id=\"attachment_7722\" aria-describedby=\"caption-attachment-7722\" style=\"width: 2500px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-7722 size-full\" src=\"https:\/\/www.hermes.com.tw\/wp-content\/uploads\/press-medicine2021-figure2-1.jpg\" alt=\"\" width=\"2500\" height=\"1236\" srcset=\"https:\/\/www.hermes.com.tw\/wp-content\/uploads\/press-medicine2021-figure2-1.jpg 2500w, https:\/\/www.hermes.com.tw\/wp-content\/uploads\/press-medicine2021-figure2-1-1000x494.jpg 1000w, https:\/\/www.hermes.com.tw\/wp-content\/uploads\/press-medicine2021-figure2-1-1920x949.jpg 1920w, https:\/\/www.hermes.com.tw\/wp-content\/uploads\/press-medicine2021-figure2-1-768x380.jpg 768w, https:\/\/www.hermes.com.tw\/wp-content\/uploads\/press-medicine2021-figure2-1-1536x759.jpg 1536w, https:\/\/www.hermes.com.tw\/wp-content\/uploads\/press-medicine2021-figure2-1-2048x1013.jpg 2048w\" sizes=\"auto, (max-width: 2500px) 100vw, 2500px\" \/><figcaption id=\"caption-attachment-7722\" class=\"wp-caption-text\">\u56fe 1\uff1a\u6731\u91cc\u96c5\u65af\u4f7f\u7528\u8fa3\u6912\u4e2d\u7684\u8fa3\u6912\u7d20\u6765\u9274\u5b9a TRPV1\uff0c\u8fd9\u662f\u4e00\u79cd\u7531\u70ed\u75db\u6fc0\u53d1\u7684\u79bb\u5b50\u901a\u9053\u3002\u786e\u5b9a\u4e86\u5176\u4ed6\u76f8\u5173\u7684\u79bb\u5b50\u901a\u9053\uff0c\u6211\u4eec\u73b0\u5728\u4e86\u89e3\u4e0d\u540c\u7684\u6e29\u5ea6\u5982\u4f55\u5728\u795e\u7ecf\u7cfb\u7edf\u4e2d\u8bf1\u5bfc\u7535\u8109\u51b2\u4fe1\u53f7\u3002(\u56fe\u7247\u6765\u6e90\uff1aTHE NOBEL PRIZE)<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p>TRPV1 \u7684\u70ed\u654f\u7279\u6027\u662f\u4e00\u9879\u91cd\u5927\u53d1\u73b0\uff0c\u5e76\u4e3a\u63ed\u5f00\u5176\u4ed6\u6e29\u5ea6\u611f\u5e94\u53d7\u4f53\u5f00\u8f9f\u4e86\u65b0\u9053\u8def\u3002\u4e4b\u540e\uff0c\u6731\u91cc\u96c5\u65af\u548c\u5e15\u5854\u666e\u8482\u5b89\uff0c\u5206\u522b\u72ec\u7acb\u4f7f\u7528\u8584\u8377\u9187\u505a\u7814\u7a76\uff0c\u5e76\u53d1\u73b0\u4f1a\u88ab\u5bd2\u51b7\u6fc0\u53d1\u7684 TRPM8 \u53d7\u4f53\u3002<\/p>\n<p>\u4e4b\u540e\uff0c\u4e0e TRPV1 \u548c TRPM8 \u76f8\u5173\u7684\u5176\u4ed6\u53d7\u4f53\uff0c\u90fd\u9646\u7eed\u786e\u8ba4\u4f1a\u5bf9\u4e0d\u540c\u7684\u6e29\u5ea6\u4ea7\u751f\u53cd\u5e94\u3002\u8bb8\u591a\u5b9e\u9a8c\u5ba4\u5f00\u5c55\u4e86\u65b0\u7684\u7814\u7a76\uff0c\u901a\u8fc7\u4f7f\u7528\u7f3a\u4e4f\u8fd9\u4e9b\u53d7\u4f53\u7684\u5c0f\u9f20\uff0c\u6765\u7814\u7a76\u8fd9\u4e9b\u901a\u9053\u5728\u70ed\u611f\u89c9\u4e2d\u7684\u4f5c\u7528\u3002<br \/>\n\u6731\u91cc\u96c5\u65af\u53d1\u73b0\u7684 TRPV1\uff0c\u4f7f\u6211\u4eec\u80fd\u591f\u66f4\u4e86\u89e3\u6e29\u5ea6\u5dee\u5982\u4f55\u5728\u795e\u7ecf\u7cfb\u7edf\u4e2d\u8bf1\u53d1\u7535\u8109\u51b2\u4fe1\u53f7\u3002<\/p>\n<p><strong>\u300c\u673a\u68b0\u529b\u300d\u523a\u6fc0\u5982\u4f55\u8f6c\u5316\u4e3a\u89e6\u89c9\uff1f<br \/>\n<\/strong><br \/>\n\u6e29\u5ea6\u7684\u53d7\u4f53\u6b63\u5728\u88ab\u9010\u6e10\u89e3\u5bc6\uff0c\u4f46\u5bf9\u4e8e\u300c\u673a\u68b0\u529b\u300d\u7684\u523a\u6fc0\u4e3a\u4f55\u53ef\u4ee5\u8f6c\u5316\u4e3a\u89e6\u89c9\u548c\u538b\u529b\uff1f\u66fe\u6709\u79d1\u5b66\u5bb6\u5728\u7ec6\u83cc\u4e0a\u53d1\u73b0\u76f8\u5173\u53d7\u4f53\uff0c\u4f46\u5173\u4e8e\u810a\u690e\u52a8\u7269\u7684\u89e6\u89c9\u673a\u5236\u4ecd\u7136\u672a\u77e5\u3002\u5e15\u5854\u666e\u8482\u5b89\uff08Scripps Research in La Jolla, California, USA\uff09\uff0c\u5e0c\u671b\u53ef\u4ee5\u627e\u5230\u8fd9\u4e2a\u96be\u4ee5\u6349\u6478\u7684\u53d7\u4f53\u5230\u5e95\u662f\u4ec0\u4e48\uff1f<\/p>\n<p>\u5e15\u5854\u666e\u8482\u5b89\u548c\u4ed6\u7684\u4f19\u4f34\u9996\u5148\u627e\u5230\u4e86\u4e00\u79cd\u7ec6\u80de\u682a\uff0c\u5f53\u5b83\u88ab\u5fae\u91cf\u5438\u7ba1\uff08micropipette\uff09\u6233\u5230\u3001\u53d7\u5230\u529b\u523a\u6fc0\u7684\u65f6\u5019\uff0c\u4f1a\u53d1\u51fa\u53ef\u6d4b\u91cf\u7684\u7535\u8109\u51b2\u4fe1\u53f7\u3002\u63a5\u7740\uff0c\u4ed6\u4eec\u8bd5\u56fe\u7f16\u7801\u4e86\u5404\u79cd\u53ef\u80fd\u4f1a\u88ab\u673a\u68b0\u529b\u6fc0\u6d3b\u7684\u79bb\u5b50\u901a\u9053\u7684\u53d7\u4f53\u7684\u57fa\u56e0\uff08\u517172\u7ec4\uff09\uff0c<\/p>\n<figure id=\"attachment_7726\" aria-describedby=\"caption-attachment-7726\" style=\"width: 2000px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-7726 size-full\" src=\"https:\/\/www.hermes.com.tw\/wp-content\/uploads\/press-medicine2021-figure3-1.jpg\" alt=\"\" width=\"2000\" height=\"1785\" srcset=\"https:\/\/www.hermes.com.tw\/wp-content\/uploads\/press-medicine2021-figure3-1.jpg 2000w, https:\/\/www.hermes.com.tw\/wp-content\/uploads\/press-medicine2021-figure3-1-672x600.jpg 672w, https:\/\/www.hermes.com.tw\/wp-content\/uploads\/press-medicine2021-figure3-1-1210x1080.jpg 1210w, https:\/\/www.hermes.com.tw\/wp-content\/uploads\/press-medicine2021-figure3-1-768x685.jpg 768w, https:\/\/www.hermes.com.tw\/wp-content\/uploads\/press-medicine2021-figure3-1-1536x1371.jpg 1536w\" sizes=\"auto, (max-width: 2000px) 100vw, 2000px\" \/><figcaption id=\"caption-attachment-7726\" class=\"wp-caption-text\">\u56fe 2\uff1a\u5e15\u5854\u666e\u8482\u5b89\u53d1\u660e\u4e86\u4e00\u7cfb\u5217\u7684\u7814\u7a76\uff0c\u8bc1\u660e Piezo2 \u79bb\u5b50\u901a\u9053\u5bf9\u89e6\u89c9\u81f3\u5173\u91cd\u8981\u3002(\u56fe\u7247\u6765\u6e90\uff1aTHE NOBEL PRIZE)<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p>\u5e76\u4e14\u627e\u5bfb\u5230\u5e95\u662f\u54ea\u4e00\u7ec4\u57fa\u56e0\u5728\u5176\u4e2d\u5360\u6709\u91cd\u8981\u5173\u952e\u3002\u7ecf\u8fc7\u641c\u7d22\uff0c\u4ed6\u4eec\u786e\u5b9a\u4e86\u4e00\u7ec4\u57fa\u56e0\uff0c\u5f53\u5b83\u4e0d\u8868\u73b0\u7684\u65f6\u5019\uff0c\u7ec6\u80de\u5bf9\u5fae\u91cf\u5438\u7ba1\u7684\u523a\u6fc0\u5b8c\u5168\u6ca1\u6709\u53cd\u5e94\u3002<br \/>\n\u56e0\u6b64\uff0c\u4e00\u79cd\u5168\u65b0\u3001\u4e4b\u524d\u5b8c\u5168\u672a\u77e5\uff0c\u5bf9\u673a\u68b0\u529b\u654f\u611f\u7684\u79bb\u5b50\u901a\u9053\u88ab\u53d1\u73b0\uff0c\u4ed6\u88ab\u547d\u540d\u4e3a\u300cPiezo1\u300d\uff0c\u4ece\u5e0c\u814a\u8bed\u4e2d\u8868\u793a\u538b\u529b\u7684\u8bcd\u300c\u00ed; p\u00edesi\u300d\u800c\u6765\u3002\u85c9\u7531\u4e0e Piezo1 \u7684\u76f8\u4f3c\u6027\uff0c\u7814\u7a76\u56e2\u961f\u627e\u5230\u4e86\u7b2c\u4e8c\u7ec4\u57fa\u56e0\uff0c\u5e76\u5c06\u5176\u547d\u540d\u4e3a\u300cPiezo2\u300d\uff0c\u5b83\u5bf9\u611f\u89c9\u795e\u7ecf\u5143\u7684\u8868\u8fbe\u6c34\u5e73\u5f88\u9ad8\u3002\u8fd1\u4e00\u6b65\u8bc1\u5b9e Piezo1 \u548c Piezo2 \u662f\u900f\u8fc7\u5bf9\u7ec6\u80de\u819c\u65bd\u52a0\u538b\u529b\u800c\u88ab\u6d3b\u5316\u7684\u79bb\u5b50\u901a\u9053\u3002<\/p>\n<p>\u5e15\u5854\u666e\u8482\u5b89\u53d1\u660e\u4e86\u4e00\u7cfb\u5217\u7684\u7814\u7a76\uff0c\u8bc1\u660e Piezo2 \u79bb\u5b50\u901a\u9053\u5bf9\u89e6\u89c9\u81f3\u5173\u91cd\u8981\uff0c\u5b83\u4e5f\u88ab\u8bc1\u660e\u5728\u91cd\u8981\u7684\u8eab\u4f53\u4f4d\u7f6e\u548c\u672c\u4f53\u611f\u89c9\u4e2d\u626e\u6f14\u91cd\u8981\u7684\u89d2\u8272\u3002Piezo1 \u548c Piezo2 \u901a\u9053\u4e5f\u88ab\u8bc1\u660e\u80fd\u8c03\u8282\u4e00\u4e9b\u91cd\u8981\u7684\u751f\u7406\u8fc7\u7a0b\uff0c\u5305\u542b\u8840\u538b\u3001\u547c\u5438\u53ca\u8180\u80f1\u63a7\u5236\u7b49\u7b49\u3002<\/p>\n<p><strong>\u8fd9\u4e00\u5207\u90fd\u8bf4\u5f97\u300c\u901a\u300d\u4e86\uff01<br \/>\n<\/strong><br \/>\n\u4eca\u5e74\u8bfa\u8d1d\u5c14\u5956\u5f97\u5956\u8005\u5bf9 TRPV1\u3001TRPM8 \u548c Piezo \u901a\u9053\u7684\u7a81\u7834\u6027\u53d1\u73b0\uff0c\u8ba9\u6211\u4eec\u80fd\u591f\u4e86\u89e3\u6e29\u5ea6\uff08\u51b7\u3001\u70ed\uff09\u548c\u673a\u68b0\u529b\u5982\u4f55\u523a\u6fc0\u795e\u7ecf\u4ea7\u751f\u51b2\u52a8\uff0c\u4f7f\u5f97\u6211\u4eec\u53ef\u4ee5\u611f\u77e5\u548c\u9002\u5e94\u5468\u56f4\u7684\u4e16\u754c\u3002TRP \u901a\u9053\u7684\u53d1\u73b0\u662f\u6211\u4eec\u611f\u77e5\u6e29\u5ea6\u7684\u91cd\u8981\u53d1\u73b0\uff0c\u4e5f\u662f\u5bf9\u4e8e\u53d7\u4f53\u7814\u7a76\u5f88\u91cd\u8981\u7684\u57fa\u77f3\u3002Piezo2 \u901a\u9053\u5219\u662f\u8d4b\u4e88\u6211\u4eec\u89e6\u89c9\u548c\u611f\u77e5\u8eab\u4f53\u5404\u79cd\u90e8\u4f4d\u7684\u4f4d\u7f6e\u548c\u8fd0\u52a8\u7684\u80fd\u529b\u3002<\/p>\n<p>\u8fd9\u4e9b\u5f00\u521b\u6027\u7684\u53d1\u73b0\uff0c\u4e0d\u53ea\u8ba9\u6211\u4eec\u77e5\u9053\u79bb\u5b50\u901a\u9053\u5bf9\u4e8e\u8bb8\u591a\u751f\u7406\u8868\u73b0\u548c\u75be\u75c5\u90fd\u81f3\u5173\u91cd\u8981\uff0c\u800c\u76f8\u5173\u7684\u77e5\u8bc6\u4e5f\u80fd\u5728\u540e\u7eed\u88ab\u5e94\u7528\u4e8e\u5404\u79cd\u75be\u75c5\u7684\u6cbb\u7597\u65b9\u5f0f\u3002<\/p>\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe loading=\"lazy\" title=\"&quot;This discovery has profoundly changed our view of how we sense the world around us.&quot;\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/Ca3VbiVaIjk?start=326&#038;feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p>\u201cThis discovery has profoundly changed our view of how we sense the world around us\u201d<br \/>\nImmediately following the announcement of the 2021 Nobel Prize in Physiology or Medicine, Professor Abdel El Manira, member of the the Nobel Assembly, spoke to reporter Lotta Fredholm about this year\u2019s awarded discovery. (<a href=\"https:\/\/www.youtube.com\/watch?v=Ca3VbiVaIjk&amp;t=326s\">Video Link<\/a>)<\/p>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n<p><strong>\u8fa3\u6912\u8fa3\u5ea6\u4e0e\u70ed\u5ea6\u5982\u4f55\u5f62\u6210 \u53f0\u6e7e\u5b66\u8005\u73b0\u8eab\u8bf4\u660e<\/strong><\/p>\n<p>(\u4e0b\u6587\u8f6c\u8f7d\u81ea\u53f0\u6e7e\u79d1\u6280\u5a92\u4f53\u4e2d\u5fc3)<br \/>\n\u53f0\u6e7e\u7814\u7a76\u9662\u751f\u7269\u533b\u5b66\u7814\u7a76\u6240\u7814\u7a76\u5458\u517c\u526f\u6240\u957f\u9648\u5fd7\u6210\u8868\u793a\uff0c\u4e24\u4f4d\u5f97\u5956\u7684\u79d1\u5b66\u5bb6\u6700\u91cd\u8981\u7684\u8d21\u732e\u662f\u53d1\u73b0\u8fa3\u6912\u7d20\u53d7\u4f53\uff08TRPV1\uff09\uff0c\u4ee5\u53ca\u673a\u68b0\u529b\u53d7\u4f53\uff08Piezo1\u3001Piezo2\uff09\uff0c\u662f\u7b2c\u4e00\u6b21\u5728\u5206\u5b50\u7684\u5c42\u6b21\u4e0a\u53d1\u73b0\u8fd9\u4e24\u4e2a\u611f\u89c9\u7684\u5bf9\u5e94\u53d7\u4f53\u3002\u8fa3\u6912\u7d20\u53d7\u4f53\u572842\u5ea6\u4ee5\u4e0a\u624d\u4f1a\u6d3b\u5316\uff0c\u4e0e\u70ed\u7684\u611f\u89c9\u6709\u5173\u3002<\/p>\n<p>\u9648\u5fd7\u6210\u8bf4\u660e\uff0cPiezo1\u7684\u91cd\u8981\u529f\u80fd\u662f\u8840\u538b\u3001\u547c\u5438\u548c\u8180\u80f1\u63a7\u5236\u3002Piezo2\u5728\u611f\u89c9\u795e\u7ecf\u7cfb\u7edf\u626e\u6f14\u91cd\u8981\u89d2\u8272\uff0c\u5305\u542b\u672c\u4f53\u611f\u89c9\u4e0e\u75db\u89c9\u7684\u673a\u68b0\u529b\u611f\u53d7\u3002<\/p>\n<p>\u4e2d\u5174\u5927\u5b66\u751f\u547d\u79d1\u5b66\u7cfb\u6559\u6388\u517c\u7cfb\u4e3b\u4efb\u6797\u8d6b\u5219\u63d0\u5230\uff0c\u795e\u7ecf\u75db\u89c9\u3001\u5185\u810f\u75db\u89c9\u7b49\u611f\u89c9\uff0c\u5bf9\u4e8e\u7ef4\u6301\u65e5\u5e38\u751f\u6d3b\u975e\u5e38\u91cd\u8981\u3002\u4efb\u804c\u4e8e\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u7684\u6731\u91cc\u96c5\u65af\uff0c\u4f7f\u7528\u8fa3\u6912\u7d20\u505a\u5b9e\u9a8c\uff0c\u53d1\u73b0\u5bf9\u8fa3\u6912\u7d20\u7684\u53cd\u5e94\u662f\u4ea7\u751f\u707c\u70ed\u7684\u611f\u89c9\uff0c\u8fdb\u4e00\u6b65\u7814\u7a76\u4e4b\u540e\u53d1\u73b0\u611f\u53d7\u8fa3\u6912\u7d20\u7684\u53d7\u4f53\uff0c\u5373\u662f\u8fa3\u6912\u7d20\u53d7\u4f531\uff08TRPV1\uff09\u3002<\/p>\n<p>\u5e15\u5854\u666e\u8482\u5b89\u7684\u7814\u7a76\uff0c\u4e3b\u8981\u662f\u4e0e\u673a\u68b0\u6027\u7684\u89e6\u89c9\u6709\u5173\u7684\u673a\u5236\uff0c\u4f8b\u5982\u9aa8\u9abc\u751f\u957f\u91cd\u5851\u65f6\u538b\u8feb\u7684\u611f\u89c9\uff0c\u4ee5\u53ca\u8840\u538b\u7b49\u3002\u76ae\u80a4\u548c\u5185\u810f\u90fd\u6709\u8fd9\u4e9b\u611f\u53d7\u5668\uff0c\u624d\u80fd\u5bf9\u5916\u754c\u53cd\u5e94\u3002<\/p>\n<p>\u53f0\u6e7e\u9633\u660e\u4ea4\u901a\u5927\u5b66\u751f\u547d\u79d1\u5b66\u9662\u9662\u957f\u8fde\u6b63\u7ae0\u8868\u793a\uff0c\u79bb\u5b50\u901a\u9053\u5206\u6210\u5f88\u591a\u7c7b\u522b\uff0c\u6709\u4e9b\u4f1a\u611f\u53d7\u70ed\u7684\u6e29\u5ea6\uff0c\u53e6\u5916\u6709\u4e9b\u4f1a\u611f\u53d7\u51b7\u7684\u6e29\u5ea6\u3002\u79bb\u5b50\u901a\u9053\u53d7\u5230\u5916\u5728\u523a\u6fc0\u540e\u5f62\u72b6\u6539\u53d8\uff0c\u662f\u672b\u68a2\u795e\u7ecf\u4ea7\u751f\u7535\u4f4d\u53d8\u5316\u7684\u5173\u952e\u3002\u8fde\u6b63\u7ae0\u63d0\u5230\uff0c\u540e\u6765\u53d1\u73b0\uff0c\u5168\u8eab\u7684\u4f53\u611f\u90fd\u6709\u5176\u76f8\u5bf9\u5e94\u7684\u79bb\u5b50\u901a\u9053\u3002\u8fd9\u4e9b\u57fa\u7840\u7814\u7a76\u5bf9\u4e8e\u73b0\u5728\u5f00\u53d1\u6b62\u75db\u836f\uff0c\u90fd\u6709\u5f88\u91cd\u8981\u7684\u8d21\u732e\u3002<br \/>\n\u9648\u5fd7\u6210\u8865\u5145\u8bf4\uff0c\u5176\u5b9e\u8fa3\u6912\u7d20\u53d7\u4f53\u5bf9\u672c\u4f53\u611f\u89c9\u5f88\u91cd\u8981\uff0c\u5bf9\u9178\u4e5f\u6709\u53cd\u5e94\uff0c\u5bf9\u673a\u68b0\u529b\u4e5f\u6709\u53cd\u5e94\uff0c\u53ea\u662f\u673a\u5236\u548cPiezo1\u3001Piezo2\u53d7\u4f53\u4e0d\u540c\uff0c\u663e\u793a\u8fa3\u6912\u7d20\u53d7\u4f53\u662f\u591a\u529f\u80fd\u7684\u79bb\u5b50\u901a\u9053\u3002\u5982\u679cPiezo2\u53d7\u4f53\u6709\u7f3a\u9677\uff0c\u672c\u4f53\u611f\u89c9\u4f1a\u6709\u95ee\u9898\uff0c\u4f8b\u5982\u4f1a\u5bb9\u6613\u6454\u5012\u3002\u9648\u5fd7\u6210\u8865\u5145\uff0c\u8fa3\u6912\u7d20\u53d7\u4f53\u5728\u672a\u6765\u7684\u5e94\u7528\u53ef\u80fd\u662f\u6d88\u708e\u4e0e\u6b62\u75db\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n<p>\u8fd9\u7c7b\u7814\u7a76\u4e5f\u53d7\u5230\u53f0\u6e7e\u5b66\u8005\u91cd\u89c6\uff0c\u9ad8\u96c4\u533b\u5b66\u5927\u5b66\u4e34\u5e8a\u533b\u5b66\u7814\u7a76\u6240\u52a9\u7406\u6559\u6388\u8c2d\u4fca\u7965\uff0c\u4e5f\u662f\u4ece\u4e8b\u7c7b\u4f3c\u7814\u7a76\u3002\u8c2d\u4fca\u7965\u8868\u793a\uff0c\u4ed6\u7684\u7814\u7a76\u662f\u53d1\u73b0\u53e6\u4e00\u79cd\u53d7\u4f53\uff08TRPM2\uff09\u7684\u79bb\u5b50\u901a\u9053\uff0c\u4e0e\u611f\u53d7\u70ed\u7684\u673a\u5236\u6709\u5173\uff0c\u5e76\u6b64\u7814\u7a76\u5df2\u57282020\u5e74\u6b63\u5f0f\u53d1\u8868\u4e8e\u300a\u81ea\u7136\u300b\uff08Nature\uff09\u671f\u520a\u4e0a\u3002<\/p>\n<p>\u56db\u4f4d\u4e13\u5bb6\u5747\u8868\u793a\uff0c\u79d1\u5b66\u5bb6\u539f\u672c\u4e00\u76f4\u627e\u4e0d\u5230\u611f\u53d7\u6e29\u5ea6\uff0c\u4ee5\u53ca\u53d7\u5916\u529b\u523a\u6fc0\u7684\u53cd\u5e94\u662f\u900f\u8fc7\u4ec0\u4e48\u673a\u5236\u3002\u5f97\u5956\u7684\u4e24\u4f4d\u79d1\u5b66\u5bb6\u8fd0\u7528\u5b9e\u9a8c\u6d4b\u91cf\u7ec6\u80de\u5bf9\u8fa3\u6912\u7d20\u6709\u53cd\u5e94\uff0c\u4ee5\u53ca\u5bf9\u529b\u4f1a\u4ea7\u751f\u7535\u4f4d\u53d8\u5316\uff0c\u627e\u5230\u8fd9\u4e9b\u611f\u89c9\u673a\u5236\uff0c\u662f\u6211\u4eec\u5185\u5728\u5982\u4f55\u611f\u53d7\u3001\u89e3\u91ca\u5e76\u4e0e\u5916\u5728\u4e16\u754c\u4e92\u52a8\u7684\u6700\u6839\u672c\u57fa\u7840\uff0c\u662f\u975e\u5e38\u91cd\u8981\u7684\u751f\u7406\u533b\u5b66\u76f8\u5173\u7814\u7a76\u57fa\u7840\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\u8cc7\u6599\u4f86\u6e90\uff1a<br \/>\nThe Nobel Prize (2021\u5e7410\u67084\u65e5)\uff1bPress release: The Nobel Prize in Physiology or Medicine 2021\uff1bThe Nobel Prize (2021\/10\/8)\uff0c\u53d6\u81ea<a href=\"https:\/\/www.nobelprize.org\/prizes\/medicine\/2021\/press-release\/\">https:\/\/www.nobelprize.org\/prizes\/medicine\/2021\/press-release\/<\/a><\/p>\n<p>PanSci (2021\u5e7410\u67084\u65e5)\uff1b\u30102021\u8bfa\u8d1d\u5c14\u751f\u7406\u6216\u533b\u5b66\u5956\u3011\u4e3a\u4f55\u4f1a\u6709\u300c\u70ed\u70ed\u7684\u3001\u523a\u523a\u7684\u300d\u611f\u89c9\uff1f\u6e29\u5ea6\u4e0e\u89e6\u89c9\u53d7\u4f53\u7684\u53d1\u73b0\uff1b\u6cdb\u79d1\u5b66 PanSci (2021\/10\/12)\uff0c\u8f6c\u8f7d\u81ea<a href=\"https:\/\/pansci.asia\/archives\/332251\">https:\/\/pansci.asia\/archives\/332251<\/a><\/p>\n<p>\u53f0\u6e7e\u79d1\u6280\u5a92\u4f53\u4e2d\u5fc3 (2021\u5e7410\u67084\u65e5)\uff1b2021\u8bfa\u8d1d\u5c14\u751f\u533b\u5956\u8bb0\u8005\u4f1a \u4f1a\u540e\u65b0\u95fb\u7a3f\uff1b\u53f0\u6e7e\u79d1\u6280\u5a92\u4f53\u4e2d\u5fc3SMC (2021\/10\/13)\uff0c\u8f6c\u8f7d\u81ea<a href=\"https:\/\/smctw.tw\/11236\/\">https:\/\/smctw.tw\/11236\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4eba\u7c7b\u611f\u53d7\u51b7\u70ed\u53ca\u89e6\u89c9\u7684\u80fd\u529b\u662f\u4e0e\u751f\u4ff1\u6765\uff0c\u4e14\u5bf9\u751f\u5b58\u800c\u8a00\u662f\u81f3\u5173\u91cd\u8981\u7684\u80fd\u529b\u3002<\/p>\n","protected":false},"author":1,"featured_media":7737,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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