{"id":2948,"date":"2019-05-28T13:31:28","date_gmt":"2019-05-28T05:31:28","guid":{"rendered":"https:\/\/www.hermes.com.tw%e7%94%9f%e5%91%bd%e7%a7%91%e5%ad%b8%e8%ab%be%e8%b2%9d%e7%88%be%e7%8d%8e%e6%96%b0%e5%af%b5\/"},"modified":"2019-08-14T09:52:06","modified_gmt":"2019-08-14T01:52:06","slug":"%e7%94%9f%e5%91%bd%e7%a7%91%e5%ad%a6%e8%af%ba%e8%b4%9d%e5%b0%94%e5%a5%96%e6%96%b0%e5%ae%a0","status":"publish","type":"post","link":"https:\/\/www.hermes.com.tw\/zh-hans\/%e7%94%9f%e5%91%bd%e7%a7%91%e5%ad%a6%e8%af%ba%e8%b4%9d%e5%b0%94%e5%a5%96%e6%96%b0%e5%ae%a0\/","title":{"rendered":"\u751f\u547d\u79d1\u5b66 \u8bfa\u8d1d\u5c14\u5956\u65b0\u5ba0"},"content":{"rendered":"

 <\/p>\n

2018\u5e74\uff0c\u8bfa\u8d1d\u5c14\u533b\u5b66\u5956\u4e0e\u5316\u5b66\u5956\uff0c\u7686\u6388\u4e0e\u751f\u533b\u9886\u57df\u76f8\u5173\uff0c\u5c24\u5176\u662f\u764c\u75c7\u6cbb\u7597\u7814\u7a76\u3002\u751f\u533b\u9886\u57df\u5df2\u6210\u4e3a\u672a\u6765\u4e16\u4ee3\u6700\u503c\u5f97\u671f\u5f85\u7684\u82cd\u7a79\u3002<\/p>\n

\u82f1\u56fd\u5251\u6865\u751f\u7269\u7814\u7a76\u5ba4\uff0c\u4e00\u4e2a\u7814\u7a76\u5ba4\u5185\uff0c\u603b\u8ba1\u5df2\u670912\u4e2a\u7814\u7a76\u4eba\u83b7\u5f97\u8bfa\u8d1d\u5c14\u5956\u6842\u51a0\u3002\u663e\u89c1\uff0c\u5bf9\u7684\u9886\u57df\u7814\u7a76\u7a81\u7834\uff0c\u5c06\u4e3a\u4eba\u7c7b\u4f5c\u51fa\u4f1f\u5927\u7684\u8d21\u732e\u3002\u73b0\u4eca\u5927\u591a\u6570\u7684\u5148\u8fdb\u764c\u75c7\u7597\u6cd5\u90fd\u662f\u4e86\u4e0d\u8d77\u7684\u79d1\u5b66\u5bb6\u65b0\u7814\u7a76\u51fa\u6765\u7684\u6297\u4f53\u836f\u7269\u3002<\/p>\n

\u5229\u4ed6\uff0c\u4e00\u76f4\u662f\u6211\u4eecDNA\u3002\u6c49\u6c11\u79d1\u6280\u8fd1\u6765\u5728\u601d\u8651\u7740\uff0c\u5982\u4f55\u5229\u7528\u6211\u4eec\u4e9b\u8bb8\u7684\u8d44\u6e90\uff0c\u80fd\u9009\u62e9\u4e00\u4e9b\u66f4\u957f\u8fdc\u3001\u6709\u610f\u4e49\u7684\u5fd7\u4e1a\uff0c\u5bf9\u4eba\u7c7b\u751f\u547d\u798f\u7949\u6709\u6240\u8d21\u732e\u3002\u4e8e\u662f\uff0c\u6211\u4eec\u5c55\u5bf9\u751f\u547d\u79d1\u5b66\u7814\u7a76\u7684\u6295\u8d44\uff0c\u5e0c\u671b\u7ed3\u5408\u6709\u5fd7\u7684\u4f19\u4f34\uff0c\u540c\u884c\u3002<\/p>\n

 <\/p>\n

\n

<\/h4>\n

2018 \u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u4ecb\u7ecd<\/strong><\/span><\/h4>\n

 <\/p>\n

2018 \u5e74\u8bfa\u8d1d\u5c14\u5956\u51fa\u7089\uff0c\u5316\u5b66\u5956\u7531\u82f1\u56fd\u79d1\u5b66\u5bb6 Sir Gregory P. Winter \u548c\u4e24\u4f4d\u7f8e\u56fd\u79d1\u5b66\u5bb6 Frances H. Arnold \u53ca George P. Smith \u83b7\u5f97\uff0c 3 \u4f4d\u5f97\u5956\u8005\u7684\u7814\u7a76\u85c9\u7531\u6a21\u62df\u81ea\u7136\u754c\u7684\u6f14\u5316\u8fc7\u7a0b\uff0c\u6700\u7ec8\u4fc3\u8fdb\u65b0\u71c3\u6599\u548c\u836f\u7269\u7684\u5f00\u53d1\uff0c\u5e76\u8fdb\u4e00\u6b65\u63a8\u52a8\u533b\u7597\u548c\u73af\u5883\u7684\u8fdb\u6b65\u3002<\/p>\n

\"\"\u25b2 \u745e\u5178\u7687\u5bb6\u5b66\u9662\u516c\u5e03\u7684\u5f97\u5956\u8005\u7684\u6d77\u62a5\uff0c\u8868\u5f70\u4ed6\u4eec\u5728\u9175\u7d20\u5b9a\u5411\u6f14\u5316\uff0c\u4ee5\u53ca\u80bd\uff08peptide\uff09\u548c\u6297\u4f53\uff08antibody\uff09\u7684\u566c\u83cc\u4f53\u5c55\u793a\u6280\u672f\u3002<\/p>\n

 <\/p>\n

\u6765\u81ea\u52a0\u5dde\u7406\u5de5\u5b66\u9662\uff08California Institute of Technology\uff09\u7684 Arnold \u662f\u7b2c\u4e94\u4f4d\u83b7\u5f97\u8d1d\u5c14\u5316\u5b66\u5956\u7684\u5973\u6027\uff0c\u4e5f\u662f\u7814\u7a76\u5b9a\u5411\u6f14\u5316\uff08directed evolution\uff09\u7684\u5148\u9a71\u4e4b\u4e00\u3002<\/p>\n

\u5b9a\u5411\u6f14\u5316\u662f\u86cb\u767d\u8d28\u5de5\u7a0b\u4f7f\u7528\u7684\u4e00\u79cd\u65b9\u6cd5\uff0c\u5b83\u80fd\u6a21\u62df\u81ea\u7136\u754c\u7b5b\u9009\u7684\u8fc7\u7a0b\uff0c\u57f9\u80b2\u51fa\u7814\u7a76\u4eba\u5458\u611f\u5174\u8da3\u6216\u6280\u672f\u4e0a\u6709\u7528\u7684\u86cb\u767d\u8d28\u3002\u8fc7\u7a0b\u5305\u62ec\u8bf1\u53d1\u57fa\u56e0\u7ecf\u5386\u8fed\u4ee3\u8f6e\u6b21\u7684\u7a81\u53d8\uff08mutagenesis\uff09\uff0c\u63a5\u7740\u7b5b\u9009\u51fa\u5e26\u6709\u6240\u9700\u7279\u5f81\u7684\u86cb\u767d\u8d28\uff08selection\uff09\uff0c\u6700\u540e\u8fdb\u884c\u6269\u589e\uff08amplification\uff09\u3002<\/p>\n

\"\"
\n\u25b2 \u5728\u9175\u7d20\u7684\u57fa\u56e0\u4e2d\u5f15\u8fdb\u968f\u673a\u7a81\u53d8\uff0c\u6765\u6a21\u62df\u5927\u81ea\u7136\u7b5b\u9009\u7684\u8fc7\u7a0b\u3002<\/p>\n

 <\/p>\n

\u7b80\u800c\u8a00\u4e4b\uff0cArnold \u5c06\u968f\u673a\u7684\u7a81\u53d8\u57fa\u56e0\u5f15\u5165\u9175\u7d20\u4e2d\uff0c\u7136\u540e\u770b\u770b\u8fd9\u4e9b\u7a81\u53d8\u80fd\u5bf9\u9175\u7d20\u9020\u6210\u4ec0\u4e48\u5f71\u54cd\u3002\u63a5\u7740\uff0c\u7b5b\u9009\u51fa\u6709\u6548\u7528\u7684\u7279\u5b9a\u7a81\u53d8\uff0c\u4f8b\u5982\uff1a\u7a81\u53d8\u4f7f\u5f97\u9175\u7d20\u80fd\u5728\u539f\u5148\u65e0\u6cd5\u8d77\u4f5c\u7528\u7684\u6eb6\u5242\u4e2d\u8fdb\u884c\u50ac\u5316\u53cd\u5e94\u3002\u5979\u8fdb\u4e00\u6b65\u91cd\u590d\u8fd9\u4e2a\u8fc7\u7a0b\uff0c\u5e76\u5c06\u7a81\u53d8\u57fa\u56e0\u518d\u6b21\u5f15\u5165\u8fd9\u4e9b\u7b5b\u9009\u51fa\u7684\u9175\u7d20\u4e2d\u3002<\/p>\n

Arnold \u7684\u7814\u7a76\u4e3a\u5404\u79cd\u9886\u57df\u63d0\u4f9b\u9002\u5408\u7684\u9175\u7d20\uff0c\u5305\u62ec\u751f\u7269\u71c3\u6599\u7684\u5f00\u53d1\u548c\u836f\u7269\u7684\u751f\u4ea7\uff0c\u5e76\u6709\u6548\u51cf\u5c11\u8bb8\u591a\u6709\u6bd2\u50ac\u5316\u5242\u7684\u4f7f\u7528\u673a\u4f1a\u3002\u300cArnold \u63d0\u51fa\u5979\u7684\u7814\u7a76\u6210\u679c\u540e\uff0c\u4fbf\u80fd\u6709\u6548\u5730\u8c03\u6574\u9175\u7d20\uff0c\u5728\u5de5\u4e1a\u73af\u5883\u4e2d\u53d1\u6325\u66f4\u597d\u7684\u6548\u679c\u3002\u5b83\u7684\u6700\u7ec8\u6210\u6548\u662f\uff0c\u5c06\u539f\u672c\u5728\u81ea\u7136\u4e2d\u9700\u8981\u82b1\u4e0a\u5341\u4ebf\u5e74\u6216\u767e\u4e07\u5e74\u7684\u8fdb\u5c55\u8fc7\u7a0b\uff0c\u964d\u4f4e\u5230\u53ef\u80fd\u4e0d\u5230\u4e00\u5468\u7684\u65f6\u95f4\u3002\u300d<\/p>\n

\u5316\u5b66\u5956\u7684\u53e6\u4e00\u534a\u5219\u662f Winter \u548c Smith \u5728\u300c\u80bd\uff08peptide\uff09\u548c\u6297\u4f53\uff08antibody\uff09\u7684\u566c\u83cc\u4f53\u5c55\u793a\uff08phage display\uff09\u300d\u7684\u7814\u7a76\u3002\u566c\u83cc\u4f53\u662f\u4e00\u79cd\u53ef\u4ee5\u611f\u67d3\u7ec6\u83cc\u5e76\u8bf1\u4f7f\u7ec6\u83cc\u7e41\u6b96\u7684\u75c5\u6bd2\u3002\u5bc6\u82cf\u91cc\u5927\u5b66\u7684Smith\u53d1\u73b0\uff0c\u4fee\u6539\u566c\u83cc\u4f53\u7684\u9057\u4f20\u7269\u8d28\u53ef\u4ee5\u6539\u53d8\u8d34\u9644\u5728\u5176\u5916\u90e8\u7684\u5206\u5b50\u3002<\/p>\n

\"\"<\/p>\n

\u25b2 \u8fd0\u7528\u566c\u83cc\u4f53\u5c55\u793a\u6280\u672f\uff0c\u79d1\u5b66\u5bb6\u80fd\u900f\u8fc7\u57fa\u56e0\u5de5\u7a0b\u8ba9\u566c\u83cc\u4f53\u643a\u5e26\u7279\u5b9a\u86cb\u767d\u8d28\uff0c\u4ee5\u63a2\u7d22\u8fd9\u4e9b\u86cb\u767d\u8d28\u5982\u4f55\u4e0e\u7279\u5b9a\u76ee\u6807\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n

 <\/p>\n

Smith \u610f\u8bc6\u5230\u8fd9\u4e2a\u7279\u5f81\u53ef\u80fd\u5f88\u597d\u7528\uff0c\u4f8b\u5982\uff1a\u5982\u679c\u4e0d\u77e5\u9053\u67d0\u6bb5\u7279\u5b9a\u57fa\u56e0\u4f1a\u5236\u9020\u51fa\u4ec0\u4e48\u86cb\u767d\u8d28\uff0c\u4fbf\u80fd\u8be5\u57fa\u56e0\u690d\u5165\u566c\u83cc\u4f53\u7684 DNA \u4e2d\uff0c\u8fd9\u4e2a\u672a\u77e5\u86cb\u767d\u8d28\u5c06\u51fa\u73b0\u5728\u566c\u83cc\u4f53\u7684\u8868\u9762\u5e76\u88ab\u8bc6\u522b\u3002\u8fd9\u4e5f\u610f\u5473\u7740\u79d1\u5b66\u5bb6\u4eec\u53ef\u4ee5\u5c06\u5927\u91cf\u672a\u77e5\u7684\u57fa\u56e0\u7247\u6bb5\u690d\u5165\u566c\u83cc\u4f53\uff0c\u770b\u770b\u662f\u5426\u80fd\u4ea7\u751f\u4efb\u4f55\u4e00\u79cd\u5df2\u77e5\u7684\u86cb\u767d\u8d28\uff0c\u8fdb\u800c\u786e\u5b9a\u54ea\u4e9b\u57fa\u56e0\u5bf9\u5e94\u5230\u54ea\u79cd\u86cb\u767d\u8d28\u3002\u8be5\u65b9\u6cd5\u8fd8\u4e3a\u79d1\u5b66\u5bb6\u4eec\u5f00\u542f\u53e6\u4e00\u6247\u5927\u95e8\uff0c\u90a3\u5c31\u662f\u900f\u8fc7\u57fa\u56e0\u5de5\u7a0b\u8ba9\u566c\u83cc\u4f53\u643a\u5e26\u7279\u5b9a\u86cb\u767d\u8d28\uff0c\u4ee5\u63a2\u7d22\u8fd9\u4e9b\u86cb\u767d\u8d28\u5982\u4f55\u4e0e\u7279\u5b9a\u76ee\u6807\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n

\u4eca\u5929\uff0c\u566c\u83cc\u4f53\u5c55\u793a\u5df2\u7ecf\u4ea7\u751f\u4e86\u53ef\u4ee5\u4e2d\u548c\u6bd2\u7d20\uff0c\u62b5\u6297\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u548c\u6cbb\u6108\u8f6c\u79fb\u6027\u764c\u75c7\u7684\u6297\u4f53\u3002<\/p>\n

Winter \u7684\u7814\u7a76\u65b9\u5411\u662f\u5c06\u5404\u79cd\u6297\u4f53\u7ed3\u5408\u4f4d\uff08antibody binding site\uff09\u7684 DNA \u690d\u5165\u566c\u83cc\u4f53\u4e2d\uff0c\u4f7f\u566c\u83cc\u4f53\u5728\u8868\u9762\u5448\u73b0\u6297\u4f53\u3002\u8fd9\u610f\u5473\u7740\u5b83\u53ef\u4ee5\u900f\u8fc7\u7b5b\u9009\u566c\u83cc\u4f53\uff0c\u6765\u627e\u5230\u4e0e\u7279\u5b9a\u5206\u5b50\u95f4\u6709\u6700\u4f73\u53cd\u5e94\u4f5c\u7528\u7684\u6297\u4f53\u3002<\/p>\n

Winter \u80fd\u4f7f\u7528\u8be5\u566c\u83cc\u4f53\u5c55\u793a\u6cd5\u6765\u751f\u4ea7\u65b0\u836f\uff0c\u4e3a\u764c\u75c7\u3001\u81ea\u4f53\u514d\u75ab\u75be\u75c5\u7b49\u7b49\u63d0\u4f9b\u6cbb\u7597\u3002\u5176\u4e2d\u5df2\u5f00\u53d1\u51fa\u7684\u4e00\u79cd\u65b0\u836f\u662f adalimumab\uff0c\u80fd\u6cbb\u7597\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001\u725b\u76ae\u7663\u548c\u708e\u75c7\u6027\u80a0\u75c5\u7684\u6297\u4f53\u836f\u7269\u3002\u300c\u73b0\u4eca\u51e0\u4e4e\u6240\u6709\u7684\u73b0\u4ee3\u7597\u6cd5\u90fd\u662f\u6297\u4f53\u836f\u7269\uff0c\u90fd\u80fd\u5229\u7528\u566c\u83cc\u4f53\u5c55\u793a\u8fd9\u6837\u7684\u6280\u672f\uff0c\u8fd9\u5b8c\u5168\u662f\u5f00\u521b\u6027\u7684\u7814\u7a76\uff0c\u5982\u679c Smith \u6ca1\u6709\u9996\u5148\u53d1\u5c55\u566c\u83cc\u4f53\u5c55\u793a\u6cd5\uff0c\u8fd9\u53ef\u80fd\u6c38\u8fdc\u4e0d\u4f1a\u53d1\u751f\u3002\u300d<\/p>\n

\u5728 2016 \u5e74\u7684\u4e00\u6b21\u91c7\u8bbf\u4e2d\uff0cWinter \u5411\u4ed6\u7684\u7b2c\u4e00\u4f4d\u764c\u75c7\u60a3\u8005\u627f\u8ba4\u4ed6\u4e0d\u77e5\u9053\u6297\u4f53\u6cbb\u7597\u662f\u5426\u6709\u6548\u3002\u800c\u4e8b\u5b9e\u4e0a\uff0c\u90a3\u6b21\u7684\u6cbb\u7597\u7ed3\u679c\u76f8\u5f53\u6210\u529f\uff0c\u4e00\u4e2a\u5de8\u5927\u7684\u80bf\u7624\u6d88\u5931\u4e86\u3002\u8fd9\u573a\u80dc\u5229\u8ba9\u5251\u6865\u5206\u5b50\u751f\u7269\u5b66\u5b9e\u9a8c\u5ba4\u7684\u7814\u7a76\u4eba\u5458\u603b\u5171\u83b7\u5f97 12 \u4e2a\u8bfa\u8d1d\u5c14\u5956\u3002<\/p>\n

\u8fd9 3 \u4f4d\u8bfa\u8d1d\u5c14\u5956\u5f97\u4e3b\u7684\u8d21\u732e\uff0c\u5c06\u4e3a\u65e5\u5e38\u751f\u6d3b\u4e2d\u8bb8\u591a\u9886\u57df\u5e26\u6765\u6539\u5584\uff0c\u5305\u62ec\u533b\u836f\u4ea7\u4e1a\u3001\u751f\u8d28\u71c3\u6599\u3001\u7eff\u8272\u50ac\u5316\u5242\u7b49\u7b49\u3002\u53d7\u5230\u5404\u754c\u79d1\u5b66\u5bb6\u7684\u5927\u529b\u8d5e\u626c\u3002<\/p>\n

 <\/p>\n

\n

<\/h4>\n

2018 \u8bfa\u8d1d\u5c14\u533b\u5b66\u5956\u4ecb\u7ecd<\/span><\/strong><\/h4>\n

 <\/p>\n

\"\"<\/p>\n

 <\/p>\n

10 \u6708 1 \u65e5\u63ed\u6653\u7684 2018 \u8bfa\u8d1d\u5c14\u533b\u5b66\u5956\uff0c\u7531\u5bf9\u6297\u764c\u514d\u75ab\u7597\u6cd5\u6709\u7740\u663e\u7740\u8d21\u732e\u7684\u7f8e\u56fd\u514d\u75ab\u5b66\u5bb6 James P. Allison \u548c\u65e5\u672c\u514d\u75ab\u5b66\u5bb6\u672c\u5eb6\u4f51\uff08Tasuku Honjo\uff092 \u4f4d\u83b7\u5f97\u8fd9\u9879\u6b8a\u8363\u3002\u7531\u4e8e\u764c\u7ec6\u80de\u6709\u590d\u6742\u673a\u5236\u80fd\u8eb2\u907f\u514d\u75ab\u7cfb\u7edf\u653b\u51fb\uff0c\u764c\u75c7\u6cbb\u7597\u603b\u662f\u975e\u5e38\u68d8\u624b\u3002\u63a5\u8fd1\u4e00\u4e2a\u4e16\u7eaa\u4ee5\u524d\uff0c\u79d1\u5b66\u5bb6\u9996\u6b21\u63d0\u51fa\u5229\u7528\u514d\u75ab\u7cfb\u7edf\u6cbb\u7597\u764c\u75c7\u7684\u60f3\u6cd5\uff0c\u4f46\u5728\u6ca1\u6709\u76f8\u5e94\u7a81\u7834\u6027\u7814\u7a76\u4e0b\uff0c\u8fd9\u79cd\u6982\u5ff5\u4e5f\u5c31\u4e00\u76f4\u88ab\u6401\u7f6e\uff0c\u76f4\u5230 Allison \u548c\u672c\u5eb6\u4f51\u7684\u53d1\u73b0\u540e\uff0c\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u624d\u6709\u673a\u4f1a\u5e94\u7528\u5728\u73b0\u5b9e\u7684\u4e34\u5e8a\u6cbb\u7597\u3002<\/p>\n

\u5728 1990 \u5e74\u4ee3\u7684\u7814\u7a76\u4e2d\uff0cAllison \u53d1\u73b0\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u5185\u8c03\u8282 T \u7ec6\u80de\u6d3b\u6027\u7684\u300c\u514d\u75ab\u68c0\u67e5\u70b9\u300d\uff08immune checkpoint\uff09\u673a\u5236\uff0c\u5e76\u5728\u5176\u4ed6\u7814\u7a76\u56e2\u961f\u63a2\u7d22\u52a0\u5f3a\u68c0\u67e5\u70b9\u6cbb\u7597\u81ea\u4f53\u514d\u75ab\u75be\u75c5\u7684\u540c\u65f6\uff0cAllison \u4e5f\u5728\u540e\u7eed\u7814\u7a76\u53d1\u73b0\u6291\u5236\u68c0\u67e5\u70b9\u80fd\u5728\u6cbb\u7597\u764c\u75c7\u5c0f\u9f20\u8eab\u4e0a\u4ea7\u751f\u663e\u7740\u6548\u679c\u3002\u800c 1992 \u5e74\uff0c\u4eac\u90fd\u5927\u5b66\u6559\u6388\u672c\u5eb6\u4f51\u5728\u72ec\u7acb\u7814\u7a76\u65f6\u53d1\u73b0\u4e86\u7b2c\u4e8c\u4e2a\u900f\u8fc7\u4e0d\u540c\u673a\u5236\u8fd0\u4f5c\u7684\u68c0\u67e5\u70b9\u5b58\u5728\u3002\u57fa\u4e8e\u8fd9\u9879\u53d1\u73b0\u7684\u6cbb\u7597\u65b9\u5f0f\uff0c\u5982\u4eca\u5728\u4e34\u5e8a\u5df2\u663e\u7740\u6539\u5584\u4e86\u60a3\u8005\u7684\u6cbb\u7597\u6548\u679c\u3002<\/p>\n

\"\"<\/p>\n

\u25b2 Allison \u7814\u7a76\u7684 CTLA-4 \u4e0e\u672c\u5eb6\u4f51\u7814\u7a76\u7684 PD-1\u5bf9\u514d\u75ab\u6297\u764c\u6cbb\u7597\u7684\u7814\u7a76\u505a\u51fa\u8bb8\u591a\u8d21\u732e\u3002<\/p>\n

 <\/p>\n

\u5728\u8fd9\u4e9b\u7814\u7a76\u4e4b\u4e0b\uff0c\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08checkpoint inhibitors\uff09\u4e5f\u5c31\u968f\u4e4b\u8bde\u751f\uff0c\u5c3d\u7ba1\u6709\u660e\u663e\u7684\u526f\u4f5c\u7528\uff0c\u4f46\u5728\u80ba\u764c\u3001\u80be\u764c\u3001\u6dcb\u5df4\u7624\u548c\u9ed1\u7d20\u7624\u7684\u6cbb\u7597\u90fd\u4ea7\u751f\u4e86\u663e\u7740\u6cbb\u7597\u6548\u679c\u3002\u76ee\u524d\u5168\u7403\u6709\u8bb8\u591a\u764c\u75c7\u7684\u68c0\u67e5\u70b9\u6cbb\u7597\u5b9e\u9a8c\u6b63\u5728\u8fdb\u884c\u3002\u8fd9\u4e9b\u53d1\u73b0\u8f6c\u53d8\u4e86\u5bf9\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u7684\u7406\u89e3\uff0c\u5e76\u53d1\u6398\u51fa\u63a7\u5236\uff0c\u751a\u81f3\u6839\u9664\u80bf\u7624\u548c\u8840\u764c\u7684\u6f5c\u529b\u3002<\/p>\n

\u300c\u5341\u5e74\u524d\uff0c\u8f6c\u6027\u9ed1\u8272\u7d20\u7624\uff08metastatic melanoma\uff09\u57fa\u672c\u65e0\u6cd5\u6cbb\u6108\uff0c\u4f46\u591a\u4e8f\u4e86 Allison \u548c\u672c\u5eb6\u4f51\u7684\u5de5\u4f5c\uff0c\u60a3\u8005\u73b0\u5728\u6709\u4e86\u771f\u6b63\u7684\u5e0c\u671b\uff0c\u8d85\u8fc7\u4e09\u5206\u4e4b\u4e00\u60a3\u8005\u83b7\u5f97\u957f\u671f\u76ca\u5904\uff0c\u751a\u81f3\u8fd8\u6709\u673a\u4f1a\u7ecf\u8fc7\u7597\u7a0b\u800c\u5eb7\u590d\u3002\u300d<\/p>\n

\u764c\u75c7\u662f\u4eba\u7c7b\u6700\u5927\u7684\u5065\u5eb7\u5371\u5bb3\uff0c\u5168\u7403\u6bcf\u5e74\u6709\u7ea61,500\u4e07\u4eba\u5f97\u5230\u764c\u75c7\uff0c\u5e76\u4e14\u9020\u6210\u5927\u4e8e820\u4e07\u4eba\u8eab\u4ea1\uff08\u76f8\u5f53\u4e8e\u5168\u5e74\u603b\u6b7b\u4ea1\u4eba\u6570\u768414.6%\uff09\u3002\u4f46\u662f\u4ece\u7f8e\u56fd\u7814\u7a76\u8c03\u67e5\u53d1\u73b0\uff0c\u764c\u75c7\u6cbb\u7597\u5b58\u6d3b\u7387\u5728\u8fc7\u53bb30\u5e74\u6765\u4e00\u76f4\u6ca1\u6709\u663e\u7740\u7684\u8fdb\u5c55\uff0c\u6cbb\u7597\u6548\u679c\u4e5f\u4e0d\u5982\u4eba\u7c7b\u9884\u671f\u7684\u6210\u529f\u3002\u76f4\u5230\u8fd1\u65e5\u6709\u5173\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u4e0e\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\uff0c\u4e8e\u7279\u5b9a\u764c\u75c7\u6cbb\u7597\u6709\u7a81\u7834\u6027\u7684\u8fdb\u5c55\uff0c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5bf9\u4e8e\u665a\u671f\u9ed1\u8272\u7d20\u80bf\u7624\uff0c\u4ece\u5148\u524d\u7684\u7684\u4e94\u5e74\u5b58\u6d3b\u7387\u7ea615\uff05\u8fdb\u5c55\u523050\uff05\u4ee5\u4e0a\u3002\u884d\u8fdb\u7684CAR-T\u6cbb\u7597\u5bf9\u4e8e\u513f\u7ae5\u6025\u6027\u8840\u764c\uff0c\u7531\u539f\u5148\u4f4e\u4e8e10\uff05\u7684\u6709\u6548\u7387\u63d0\u9ad8\u8fbe85\uff05\u4ee5\u4e0a\uff0c\u4e24\u8005\u6210\u4e3a\u764c\u75c7\u6cbb\u7597\u7684\u91cd\u8981\u65b9\u6cd5\u3002<\/p>\n

2018\u5e74\u7684\u8bfa\u8d1d\u5c14\u533b\u5b66\u5956\u9881\u53d1\u7ed9\u7814\u7a76\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7684\u4e24\u4f4d\u514d\u75ab\u5b66\u5bb6\uff0c\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u9881\u53d1\u7ed9\u53d1\u660e\u548c\u5e94\u7528\u566c\u83cc\u4f53\u8868\u73b0\u6280\u672f(phage display)\u548c\u86cb\u767d\u8d28\u5b9a\u5411\u6f14\u5316\u6280\u672f(directed evolution)\u7684\u4e09\u4f4d\u79d1\u5b66\u5bb6\u3002\u4eca\u65e5\u7684\u751f\u533b\u79d1\u5b66\u5bb6\u4eec\u7ed3\u5408\u4e0a\u8ff0\u79d1\u5b66\u5bb6\u53d1\u660e\u7684\u65b9\u6cd5\u7528\u566c\u83cc\u4f53\u6765\u5b9a\u5411\u6f14\u5316\u6297\u4f53\u86cb\u767d\u8d28\u3002\u5229\u7528\u55dc\u83cc\u4f53\u5448\u73b0\u6cd5\u6240\u5efa\u7acb\u7684\u6297\u4f53\u5e93\uff0c\u8fde\u7ed3\u55dc\u83cc\u4f53\u8868\u9762\u5206\u5b50\u6240\u94fe\u63a5\u6297\u4f53\u7247\u6bb5\u4e0e\u5176\u57fa\u56e0\u4fe1\u606f\uff0c\u63d0\u4f9b\u9ad8\u6548\u7387\u5355\u682a\u6297\u4f53\u7684\u7b5b\u9009\u65b9\u6cd5\u3002<\/p>\n

 <\/p>\n

\u53c2\u8003\u6570\u636e<\/p>\n

    \n
  1. \u674e\u6021\u8431 (2018 \u5e74 10 \u6708 04 \u65e5 1:32)\u3002\u3010\u8bfa\u8d1d\u5c14 2018\u3011\u4fc3\u8fdb\u751f\u8d28\u80fd\u548c\u65b0\u836f\u5f00\u53d1\uff0c\u5316\u5b66\u5956\u9881\u7ed9\u86cb\u767d\u8d28\u6f14\u5316\u7814\u7a76\u53ca\u57fa\u56e0\u5de5\u7a0b\u5de5\u5177\u3002\u79d1\u6280\u65b0\u62a5TechNews\u30022018.11.16\uff0c\u53d6\u81eahttp:\/\/technews.tw\/2018\/10\/04\/nobel-chemistry-2018-for-protein-evolution-and-gentic-enginner-tools\/<\/li>\n
  2. Nana Ho (2018 \u5e74 10 \u6708 02 \u65e5 14:21)\u3002\u3010\u8bfa\u8d1d\u5c14\u5956 2018\u3011\u533b\u5b66\u5956\u51fa\u7089\uff0c\u764c\u75c7\u514d\u75ab\u7597\u6cd5 2 \u5b66\u8005\u83b7\u5f97\u6b8a\u8363\u3002\u79d1\u6280\u65b0\u62a5TechNews\u30022018.11.16\uff0c\u53d6\u81eahttps:\/\/technews.tw\/2018\/10\/02\/2018-nobel-prize-for-medicine\/<\/li>\n<\/ol>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    2018\u5e74\uff0c\u8bfa\u8d1d\u5c14\u533b\u5b66\u5956\u4e0e\u5316\u5b66\u5956\uff0c\u7686\u6388\u4e0e\u751f\u533b\u9886\u57df\u76f8\u5173\uff0c\u5c24\u5176\u764c\u75c7\u6cbb\u7597\u7814\u7a76\u3002<\/p>\n","protected":false},"author":1,"featured_media":2583,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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